http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-109485664-B
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07F5-02 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07F5-02 |
| filingDate | 2017-09-12-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2022-03-08-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2022-03-08-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-109485664-B |
| titleOfInvention | Preparation process of antifungal medicine tavaboroluo |
| abstract | The invention relates to a preparation process of an antifungal medicament Tavaborole (Tavaborole), which comprises the following reaction steps: taking 2-bromo-5-fluorobenzaldehyde as an initial material, reacting with pinacol boric acid ester in the presence of a palladium catalyst and a solvent to generate 2-pinacol boron-based-5-fluorobenzaldehyde (TAV-A), reducing and ring-closing to generate a product tavaborole, and adjusting the pH value of a reaction solution by using dilute alkali liquor after treatment to separate out tavaborole. The preparation process has the advantages of short reaction steps, mild and safe conditions, easy operation, high yield, environmental friendliness and suitability for industrial production. |
| priorityDate | 2017-09-12-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 166.