http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-109485617-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_5df00e06064d56f9cd68ecedcfc06144 |
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/Y02P20-55 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D277-28 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D277-28 |
| filingDate | 2018-12-11-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_7a93052296c22b783d4a6e515e144f1e http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_09400a30c2b347d4cf282649cf71b5b4 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_2935eb7568ed9c755d9d0d0891a65897 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_fe0a00c0968bc03d139a3595101e0740 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_1a6380a0fd1a301c051ac90633acdc0c |
| publicationDate | 2019-03-19-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-109485617-A |
| titleOfInvention | A kind of preparation method of N-methyl-2-isopropyl-4-thiazolemethanamine |
| abstract | The invention provides a preparation method of N-methyl-2-isopropyl-4-thiazolemethanamine, relates to the technical field of pharmaceutical synthesis, and solves the problem of the current N-methyl-2-isopropyl ritonavir intermediate. The preparation method of base-4-thiazolemethanamine has the technical problems of high toxicity and unfriendly environment. The preparation method comprises the following steps: (1) acylation-cyclization reaction; (2) aromatization-substitution reaction; (3) reduction reaction. The preparation method of N-methyl-2-isopropyl-4-thiazole methylamine provided by the present invention, by using cheap and easily available isobutyryl chloride and cysteine methyl ester hydrochloride as raw materials; by acylation- The compound is synthesized in three steps: cyclization reaction, aromatization-substitution reaction, and reduction reaction; compared with the existing preparation method, it has the advantages of green environmental protection, easy large-scale industrial production and high yield, and has good application prospects. |
| priorityDate | 2018-12-11-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 84.