http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-109467551-B
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C09K2211-1088 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C09K2211-1029 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C09K11-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D405-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N21-6486 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D405-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C09K11-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01N21-64 |
| filingDate | 2018-10-12-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2021-12-14-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2021-12-14-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-109467551-B |
| titleOfInvention | Preparation process of coumarin fluorescent probe molecule for selectively detecting GSH |
| abstract | A preparation process of coumarin fluorescent probe molecules for selectively detecting GSH comprises the following steps: dissolving N-2-ethanol-based-5-chloro-2, 3, 3-trimethylindole and 3-aldehyde-7-diethylamino coumarin in absolute ethyl alcohol as a solvent, dropwise adding a catalytic amount of glacial acetic acid into the solution, refluxing, gradually changing the solution into a clear green solution in the reaction process, generating a precipitate after the reaction is completed, filtering, leaching a filter cake with diethyl ether, and obtaining a brownish green solid with metallic luster as a compound I, wherein the yield of the intermediate product reaches 90%. And dissolving the obtained compound I in a solvent dichloromethane, adding a proper amount of triethylamine, stirring at room temperature to obtain a solution which turns yellow, and performing spin drying on the solvent to obtain a compound II, wherein the yield of the final product, namely the compound II, is 86%. Simple steps, easy obtaining of products and extremely high yield. The compound II obtained by the process has selective recognition on Glutathione (GSH). |
| priorityDate | 2018-10-12-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 50.