http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-109457030-B
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Q2600-16 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Q2600-156 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Q2600-158 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Q2600-154 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Q1-6851 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N33-57449 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N33-57442 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Q1-6886 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01N33-574 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12Q1-6886 |
| filingDate | 2013-10-17-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2022-02-18-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2022-02-18-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-109457030-B |
| titleOfInvention | Papanicolaou test for ovarian and endometrial cancer |
| abstract | This application relates to the Papanicolaou test for ovarian and endometrial cancer. The recently developed liquid-based Papanicolaou (Pap) smear allows not only cytological evaluation but also DNA collection for the detection of the cervical cancer pathogen HPV. The present invention tests these samples to detect somatic mutations present in rare tumor cells that can accumulate in the cervix once expelled from endometrial and ovarian cancers. A panel of commonly mutated genes in endometrial and ovarian cancers was collected and used to identify mutations in all 46 endometrial or cervical cancer tissue samples. The present invention was also able to identify the same mutation in DNA from liquid Pap smears in 100% of endometrial cancers (24 of 24) and 41% of ovarian cancers (9 of 22). The present invention develops sequence-based methods to interrogate mutations in 12 genes in a single liquid Pap smear without prior knowledge of tumor genotypes. |
| priorityDate | 2012-10-29-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 168.