http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-109456322-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_883c38ff4c4375702c777d2d7dbec293 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D471-04 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D471-04 |
| filingDate | 2018-11-10-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_5f4bb833c9b0b846b29277b3ec33949d |
| publicationDate | 2019-03-12-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-109456322-A |
| titleOfInvention | A kind of synthetic method of medicine intermediate 5- azaindole |
| abstract | The invention discloses a kind of synthetic methods of medicine intermediate 5- azaindole, the following steps are included: after 3- methyl -4-aminopyridine is mixed with acetone, it is heated to 40-60 DEG C, oxalate is added thereto after catalyst is added, and under stirring condition, carries out back flow reaction 1-2h, filtering, filtrate is evaporated under reduced pressure, is recrystallized, 4-aminopyridine -3- pyruvate is made；It is added into DMA, salicylic acid is added and is stirring evenly and then adding into FeO, is heated to 60-70 DEG C, be stirred at reflux reaction 2-3h, filtrate is evaporated under reduced pressure by filtering, and 5- azaindole -2- formic acid is made；After it is mixed with carbon tetrachloride, it is heated to 70-90 DEG C, ZnO is added and is uniformly mixed, after being stirred at reflux reaction 2-3h, filtrate is evaporated under reduced pressure by filtering, and 5- azaindole is made.The synthetic method of the application is easy to operate, and mild condition, by-product is less, and product purity is high, and product yield is higher. |
| priorityDate | 2018-11-10-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 62.