http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-109453187-B
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K47-6863 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-713 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K47-6803 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-713 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K47-68 |
| filingDate | 2018-09-27-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2020-12-29-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2020-12-29-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-109453187-B |
| titleOfInvention | Antibody nucleic acid drug conjugate with dual enzyme sensitivity characteristics and preparation method and application thereof |
| abstract | The invention belongs to the field of pharmaceutical preparations and clinical pharmacy, and relates to an antibody nucleic acid drug conjugate with dual enzyme sensitivity characteristics, and a preparation method and application thereof. The antibody nucleic acid drug conjugate has a structure shown in A-m-X-Y-B, wherein A is an antibody, X is a membrane-penetrating peptide covalently connected with A through a short peptide m, Y is a flexible chain segment covalently connected with X, and B is a nucleic acid drug covalently connected with Y. The antibody nucleic acid drug conjugate has universality, can be used as a plurality of nucleic acid drug delivery systems, and also provides theoretical support and technical reference for the clinical transformation of the near step. In addition, the antibody nucleic acid drug conjugates of the present invention can also be used as in vitro drug screening. The nucleic acid conjugates described above may be used as positive or negative controls depending on the purpose of in vitro screening in different drug studies. |
| priorityDate | 2018-09-27-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 96.