| abstract |
The invention provides a method for preparing a novel non-natural antioxidant peptide, belonging to the field of biomedicine. The method for synthesizing the novel polypeptide is as follows: Fmoc-Pro(Boc)-OH is subjected to resin grafting reaction, and then combined with Pro or Trp amino acid, bovine The sulfonic acid carries out a ligation reaction to obtain novel polypeptides whose structures are Tau‑Trp‑Pro, Trp‑Tau‑Pro, Tau‑Trp‑Pro‑Pro, Trp‑Pro‑Tau‑Pro, Trp‑Tau‑Pro‑Pro, etc.; In the process, the Fmoc group was removed using a combination of deprotecting agents: piperidine, potassium tert-butoxide and HOBT. In the present invention, taurine is reacted with blood clams tripeptide Trp-Pro-Pro to obtain a novel polypeptide with enhanced antioxidant activity or anti-cancer activity, the amino group is completely deprotected in the polypeptide synthesis process, and the polypeptide synthesis purity is high. |