http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-109438541-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_f7db9565eff81c4dba42c5633ccb4feb |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07J17-005 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07J17-00 |
| filingDate | 2018-12-10-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_59299768b4f5cff12fd661c188859ffb http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_26f11ff7bf358706e886771db9e5be58 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_35d14c98ac6c3ab2aadab3f35f47263d http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_d00891d3853b3bc66818216cdf5898ce http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_cf8d863a078958ac6474a60dbaf0b0c5 |
| publicationDate | 2019-03-08-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-109438541-A |
| titleOfInvention | Semi-synthetic method of new ginsenoside HPD |
| abstract | The invention relates to a semi-synthetic method of new ginsenoside HPD, which belongs to the semi-synthetic method of compounds. Including the total saponins of Panax ginseng to realize grouping of diol group saponins and triol group saponins through alkali precipitation, and then under the condition of high temperature and strong alkali, the diol group saponins are hydrolyzed to form (20S)-protopanaxadiol, under the action of DMAP, and acetic acid. Anhydride reaction to obtain acetylated PPD, then under the effect of aqueous sulfuric acid, 25-hydroxyacetyl PPD is obtained through Markov addition, and finally under the effect of potassium tert-butoxide, 25-ene-acetyl is eliminated through anti-Zaytsev's rule PPD, then through hydrolysis reaction to obtain 25-ene-PPD, respectively add in 1,4-dioxane, adjust pH value, add oxidizing agent, heat to reflux, filter and concentrate the filtrate to obtain crude new ginsenoside HPD, after The pure product was obtained by column chromatography and recrystallization. The advantages are that the source of raw materials is easily available, the operation is simple, the reaction conditions are mild, the production period is short, the synthesis route is concise and reasonable, the yield is high, and the method is suitable for industrial production. |
| priorityDate | 2018-12-10-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 77.