http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-109438534-B
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07H15-18 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07H1-00 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07H15-18 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07H1-00 |
| filingDate | 2018-11-16-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2020-09-29-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2020-09-29-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-109438534-B |
| titleOfInvention | Synthetic method of fondaparinux sodium monosaccharide intermediate |
| abstract | The invention discloses a synthesis method of fondaparinux sodium monosaccharide intermediate, which takes 1, 2-O-isopropylidene-3-O-benzyl-alpha-D-glucopyranose as a raw material, and the intermediate undergoes an esterification reaction with benzoic acid, an esterification reaction with substituent sulfonic anhydride and/or substituent sulfonyl chloride, a hydrolysis reaction and a reaction by adding sulfuric acid aqueous solution, thus obtaining fondaparinux sodium monosaccharide fragment intermediate 1, 6-dehydration-3-O-benzyl-beta-L-idopyranose. The synthesis method has the advantages of simple process, less side reaction impurities and high yield, and is suitable for process amplification synthesis to meet the industrial production of fondaparinux sodium. |
| priorityDate | 2018-11-16-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 183.