http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-109438363-B
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/Y02P20-55 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D239-22 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D239-22 |
| filingDate | 2018-10-31-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2022-04-29-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2022-04-29-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-109438363-B |
| titleOfInvention | Liquid-phase high-purity large-scale synthesis method of cyclic (leucyl-arginyl) dipeptide salt |
| abstract | The invention discloses a liquid-phase high-purity large-scale synthesis method of a cyclo (leucyl-arginyl) dipeptide salt, which comprises the steps of reacting N-alpha protected leucine with N-hydroxysuccinimide under the action of N, N '-dicyclohexylcarbodiimide or N, N' -diisopropylcarbodiimide to generate active ester, and then reacting with arginine (nitro) methyl ester under an alkaline condition to generate N-alpha-leucyl arginine (nitro) methyl ester; deprotection and cyclization of N-alpha-leucyl arginine (nitryl) methyl ester, hydrogenation and removal of nitryl protection, and salification to obtain the cyclic (leucyl-arginyl) dipeptide salt. The method has the advantages of simple operation, mild conditions, low cost, environmental protection, high purity of the synthesized cyclo (leucyl-arginyl) dipeptide salt and suitability for large-scale production. |
| priorityDate | 2018-10-31-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 79.