| abstract |
The invention discloses the synthetic methods of one kind sulfamide compound as shown in formula (2), using diazonium salt as reaction raw materials, under the action of inorganic nitrogen reagent, inorganic sulfur dioxide reagent, additive, phosphonate reagent, under the conditions of 60-100 DEG C, reaction obtains all kinds of sulfamide compounds in a solvent.The present invention avoids tradition using unstable acyl chlorides and synthesizes sulfonamide with the multistep processes that amine is condensed by the way that under no metal catalyzed conditions, using inorganic salts as nitrogen-atoms source and source of sulfur dioxide, a step constructs to obtain sulfamide compound；The sulfonamide synthetic method developed through the invention can further apply the synthesis of arthritis drug celecoxib and antipsychotics Sulpiride. |