http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-109438267-B

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filingDate 2018-11-29-04:00^^<http://www.w3.org/2001/XMLSchema#date>
grantDate 2021-06-01-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationDate 2021-06-01-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber CN-109438267-B
titleOfInvention Bifunctional complexing agent containing tetraphenylethylene and preparation method and application thereof
abstract The invention relates to a bifunctional complexing agent containing tetraphenylethylene, a preparation method and application thereof. The invention is realized by repairingThe structure of the tetraphenylethylene can be complexed 68 Ga 3+ The double-functional group complexing agent of the radioactive nuclide has the functions of fluorescence and Positron Emission Tomography (PET) double imaging, is combined with different targeting molecules, and can be used for the targeted diagnosis of different types of diseases. The bifunctional complexing agent is expected to have wide application in the research and development of novel medicines. The bifunctional complexing agent of the invention has the advantages that: a) both fluorescent and complexing 68 Ga 3+ ;b) 68 Ga 3+ The marking condition is mild, and the yield is high; c) combined with different targeting molecules, a series of disease diagnosis medicines with fluorescence and PET dual imaging can be developed; d) can also be applied to Fe 3+ ,Cu 2+ And (3) rapidly detecting the metal ions.
priorityDate 2018-11-29-04:00^^<http://www.w3.org/2001/XMLSchema#date>
type http://data.epo.org/linked-data/def/patent/Publication

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