http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-109438230-B
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C67-08 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C51-363 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C69-78 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C67-08 |
| filingDate | 2018-11-26-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2022-04-22-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2022-04-22-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-109438230-B |
| titleOfInvention | Synthetic method of adapalene intermediate 6-bromo-2-naphthoate |
| abstract | The synthesis method of the adapalene intermediate 6-bromo-2-naphthoate comprises the following steps: 1) uniformly mixing 2-naphthoic acid and an organic solvent, adding a catalyst, stirring, introducing protective gas, controlling the pressure to be 4-7 atmospheric pressures, controlling the temperature to be 130-155 ℃, maintaining for 50-70 min, then dropwise adding a mixed aqueous solution containing bromide and benzenesulfonic acid, dropwise adding an aqueous solution containing only hypobromite, controlling the total dropwise adding time to be 90-150 min, after dropwise adding is finished, heating the system to be 165-180 ℃, boosting the pressure to 11-17 atmospheric pressures, and continuing to react for 5-7 h; 2) and filtering to remove solids while the solution is hot, adding the solution into ice water with the weight of 3-5 times that of the filtrate, and extracting, drying, concentrating and evaporating to remove the solvent to obtain the product. The synthetic method has high yield and no harmful substance emission. |
| priorityDate | 2018-11-26-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 97.