| abstract |
The invention provides a targeted composite exosomes and a preparation method thereof, and belongs to the technical field of medicine. The method comprises the following steps: 1) using a targeting polypeptide to perform targeted modification of the exosome to obtain an exosomes having a membrane modified target polypeptide; 2) modifying the membrane with an exosome, a drug, and a nanometer targeting the polypeptide. The ferric oxide aqueous solution is mixed with the electroporation buffer, and electroporated at 2 to 6 ° C, and then incubated at 35 to 40 ° C for 25 to 35 minutes to obtain a targeted composite exosomes. The exosomes prepared by the invention have high active targeting ability. |