http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-109432430-B
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-7088 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-704 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K45-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-4745 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-00 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-704 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-7088 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-4745 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K45-06 |
| filingDate | 2018-11-22-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2021-12-17-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2021-12-17-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-109432430-B |
| titleOfInvention | SiRNA and anticancer drug hydrophobic compound and preparation method and application thereof |
| abstract | The invention discloses a hydrophobic compound of siRNA and anticancer drug, a preparation method and application thereof, and HIP [ siRNA and anticancer drug ] is prepared by the method through Hydrophobic Ion Pairing (HIP)]The compound is encapsulated in a PEG-b-PLA nano-carrier, and the synergistic anticancer effect is achieved. The method comprises the following steps: (1) adding water soluble anticancer drug into siRNA water solution, incubating at room temperature, centrifuging, and collecting the HIP [ siRNA and anticancer drug]A complex; (2) preparation of NP [ siRNA & anticancer drug] And (5) verifying the synergistic anticancer effect. The siRNA and the anticancer drug hydrophobic compound prepared by the invention can be easily encapsulated in a PEG-b-PLA nano carrier, a new way is provided for co-delivery of the siRNA and the water-soluble anticancer drug, the siRNA and the water-soluble anticancer drug can play a role in synergy and antitumor when combined, and the siRNA and the water-soluble anticancer drug hydrophobic compound have great clinical application value. |
| priorityDate | 2018-11-22-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 54.