http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-109432057-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_3970ff2929243c84b2f197df598b9c59 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K9-0065 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K9-5042 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-365 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K9-5036 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-122 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K9-501 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-337 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-337 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-122 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K47-38 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K47-36 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K47-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-365 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K9-52 |
| filingDate | 2018-12-24-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_23b2648a6070a4940517c92af70e6a6a http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_ffe4c444da98bf5a68dcfcf312b38042 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_47f87b2e133e133db04041f383bfcd0d |
| publicationDate | 2019-03-08-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-109432057-A |
| titleOfInvention | Intragastric positioning drug release pellet and preparation method thereof |
| abstract | The invention provides a preparation method of intragastric positioning drug release pellets, comprising the following steps: (1) preparing a micelle suspension: dissolving template molecules, pluronic F127 and Tween 80 in absolute ethanol, minus After removing the solvent by pressure, suspending with chitosan HCl solution, lyophilizing to obtain micelles, adding micelles to HCl solution to fully disperse the micelles; (2) preparing sodium carboxymethylcellulose suspension: carboxy Methylcellulose sodium is added to the HCl solution and fully dispersed; (3) Ion crosslinking method: the sodium carboxymethylcellulose suspension and the micelle suspension are mixed, and the sodium hydrogencarbonate is added and stirred for a while, then the above The mixed suspension was slowly dropped into an aqueous solution of aluminum chloride to form a porous pellet, which was filtered and washed, and then dried at a low temperature to obtain a gastric intra-positioning release pellet. The invention can effectively prolong the gastric retention time of the drug through the floating of gastric juice and the adhesion of gastric mucosa, enhance the clinical curative effect of the medicine, reduce the frequency of taking the medicine, increase the compliance of the patient, and has simple preparation process and can be industrialized production. |
| isCitedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-113209034-A |
| priorityDate | 2018-12-24-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 49.