http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-109432047-B
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K9-5169 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P11-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K9-5146 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K9-5153 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-122 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-519 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K47-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K47-34 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K47-42 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K9-51 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-122 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P11-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-519 |
| filingDate | 2018-10-29-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2021-07-20-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2021-07-20-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-109432047-B |
| titleOfInvention | Reverse pulmonary fibrosis nano preparation and preparation method thereof |
| abstract | The invention discloses a reverse pulmonary fibrosis nano preparation and a preparation method thereof, wherein the E5 and polypeptide Z modified nano preparation and a carrier thereof are synthesized, and the nano preparation targets receptors of circulating fiber cells CXCR4, CCR2 and CCR7 through E5 so as to reach a pulmonary fibrosis injury part at a fixed point and avoid being wrapped and removed by in vivo macrophages and proteins; the polypeptide Z can specifically target the alveolar epithelial cell II of the high-expression integrin receptor alpha v beta 6, so that the high-efficiency targeted delivery nano preparation is realized. The nano preparation contains antioxidant and/or fibroblast activation inhibitor, and achieves the purpose of reversing pulmonary fibrosis by regulating the oxidative stress level of alveolar epithelial cells II and inhibiting the fibroblast activation through double-channel regulation respectively. |
| priorityDate | 2018-10-29-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 206.