| abstract |
Provided herein are H1.0K180me2 antibodies, H1.0K180me2 proteins, and H1.0K180me2 peptides, and methods for diagnosis and treatment. These H1.0K180me2 antibodies, H1.0K180me2 proteins and H1.0K180me2 peptides can be used to treat diseases or conditions associated with methylated H1.0 in an individual. These H1.0K180me2 antibodies, H1.0K180me2 proteins and H1.0K180me2 peptides can also be used to detect and quantify histone H1.0 proteins that contain a dimethylated lysine at lysine residue 180 (H1.0K180me2) or Fragments thereof; such compositions and methods can be used to detect replicative aging, DNA damage, genotoxic stress, radiation exposure, Alzheimer's disease, can be used to monitor treatment regimens, patient stratification, drug screening, and can be used as Markers of biological aging in the system. |