| abstract |
The invention discloses a tumor necrosis factor related apoptosis inducing ligand variant, which is tumor necrosis factor related apoptosis inducing ligand variantDeath inducing ligand and Z PDGFRβ The fusion protein of, Z PDGFRβ Is connected with the N terminal or the C terminal of the TRAIL through a linker. The invention also discloses a nucleotide sequence, a recombinant vector and a recombinant bacterium comprising the nucleotide sequence, and a preparation method and application of the variant. The TRAIL variant protein Z-hTRAIL has good tumor killing activity, and also has definite curative effect on liver fibrosis, and has good clinical application prospect. |