http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-109400680-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_3821cb507e6acd852b6f4af435621a81 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K7-56 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K7-56 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K1-30 |
| filingDate | 2018-12-07-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_091272b5dcee2aa1c44247df70058860 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_eaf4870b67fd38dea43cf92404d8c1f0 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_96a8d3c702cb1824adadeae07c521232 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_40cc2d954d2508e43acd5396bac16200 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_dea1893b461c706f5f9f88c032e38b56 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_729faf961e84480261584feeaf9ed0db http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_b6e3fe85120dfabb24131b6892a18693 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_a1046a8f3175bc583a96997404d09a42 |
| publicationDate | 2019-03-01-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-109400680-A |
| titleOfInvention | A kind of crystallization purification method of caspofungin precursor pneumocandinB0 |
| abstract | The invention discloses a method for crystallization and purification of caspofungin precursor pneumocandinB 0 , comprising the following steps: Step A, heating and dissolving crude PB 0 in an alcoholic solution containing an organic acid at a certain concentration, and dissolving the crude PB 0 product Step B, adding an organic solvent and a certain amount of inorganic salt, stirring at a certain temperature to make it crystallize, continuing to add an organic solvent, stirring at a temperature, and filtering to obtain high-purity PB 0 . By using common and low-toxic organic reagents, the present invention carries out the crystallization and purification operation of PB 0 , which is not only simple and easy to operate, but also can control the content of impurity A in PB 0 to obtain high-purity caspofungin precursor. The invention has low requirements on equipment, uses low-toxicity and easy-to-obtain reagents, and is suitable for industrial production, thereby providing a high-quality source of raw materials for the preparation of caspofungin. |
| isCitedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2023115523-A1 |
| priorityDate | 2018-12-07-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 66.