http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-109400541-B
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D249-08 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D249-08 |
| filingDate | 2018-12-04-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2022-05-17-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2022-05-17-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-109400541-B |
| titleOfInvention | Process for the preparation of cyproconazole from 1-chloro-2- (4-chlorophenyl) -3-methyl-4-penten-2-ol |
| abstract | The invention relates to the field of organic synthesis, in particular to a method for preparing cyproconazole by 1-chloro-2- (4-chlorphenyl) -3-methyl-4-pentene-2-alcohol, which comprises the following steps: (1) nucleophilic addition reaction of 2, 4' -dichloroacetophenone and Grignard reagent or organic zinc reagent to produce 1-chloro-2- (4-chlorophenyl) -3-methyl-4-pentene-2-ol, 2- (4-chlorophenyl) -2- (but-3-en-2-yl) -ethylene oxide or their mixture; (2) cyclizing the product obtained in the step (1) and methylene dihalide to obtain 1-chloro-2- (4-chlorphenyl) -3-cyclopropyl butyl-2-alcohol, 2- (4-chlorphenyl) -2- (1-cyclopropyl ethyl) -ethylene oxide or a mixture of the two; (3) and (3) performing nucleophilic substitution reaction on the product obtained in the step (2) and 1,2, 4-triazole or 1,2, 4-triazole salt to obtain cyproconazole. The preparation method of cyproconazole provided by the invention has the advantages of short route and high yield, does not use a sulfur reagent with foul smell, a highly toxic reagent and a noble metal catalyst in the reaction process, and is suitable for large-scale industrial production. |
| priorityDate | 2018-04-03-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 115.