http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-109395102-B
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K49-1866 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K49-1863 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K49-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K49-12 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K49-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K49-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K49-18 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K47-36 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K47-42 |
| filingDate | 2018-11-13-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2021-08-17-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2021-08-17-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-109395102-B |
| titleOfInvention | Pancreatic cancer double-targeting polymer magnetic nanoparticle and preparation method and application thereof |
| abstract | A pancreatic cancer double-targeting polymer magnetic nanoparticle is prepared from the following components by the following method: CKAAKN-hyaluronic acid-vitamin E succinate polymer micelle, ferroferric oxide magnetic nanoparticle solution and deionized water, wherein CKAAKN polypeptide modified hyaluronic acid-vitamin E succinate copolymer is wrapped by ultra-small paramagnetic Fe 3 O 4 The polymer magnetic nanoparticle which is targeted and modified by CKAAKN polypeptide can simulate the specific combination of Wnt protein and a pancreatic cancer cell membrane receptor through a Wnt signal path, and simultaneously the surface of a tumor cell can also highly express a hyaluronic acid receptor, namely CD44 and a hyaluronic acid mediated automatic Receptor (RHAMM), so that pancreatic cancer cells can be specifically targeted in the early diagnosis of pancreatic cancer, and a double-targeting magnetic resonance contrast agent with stronger specificity and imaging capability is provided for the early diagnosis of pancreatic cancer. |
| priorityDate | 2018-11-13-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 82.