http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-109384833-B
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N2333-922 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N15-902 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Q1-44 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K14-195 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N9-22 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12Q1-44 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K14-195 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-55 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-90 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N9-22 |
| filingDate | 2017-08-04-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2021-04-27-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2021-04-27-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-109384833-B |
| titleOfInvention | TALE RVD for specifically recognizing methylated modified DNA base and application thereof |
| abstract | The present invention identifies RVDs with recognition preferences for 5mC, 5hmC and 6mA, with different binding properties for these apparent modifications. Methylation-dependent gene activation, efficient genome editing, and targeted detection of 5hmC can be achieved using these RVDs. The invention therefore provides isolated DNA-binding polypeptides comprising TALEs, fusion proteins, polynucleotides, vectors comprising polynucleotides, and host cells, and uses of TALE repeat domain-containing proteins in the preparation of reagents for detecting methylated bases in a target gene target sequence, as well as methods of targeted binding of a target sequence of a target gene in a cell. |
| priorityDate | 2017-08-04-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 84.