http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-109381470-B
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-7048 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-58 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-58 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-7048 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P35-00 |
| filingDate | 2018-10-23-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2021-07-30-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2021-07-30-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-109381470-B |
| titleOfInvention | C21 steroid saponification compound in marsdenia tenacissima and application thereof |
| abstract | The invention relates to a C21 steroid saponin compound and application thereof in preparing anti-lung cancer drugs. The biological experiment result shows that the compound can inhibit the migration of tumor cells and make the tumor cells in the G0/G1 stage. In addition, the apoptosis of tumor cells can be induced by up-regulating Bax and down-regulating Bcl-2 expression, thereby releasing Cytochrome c and finally activating Caspase 3 and Caspase 9. Caspase 8 may also be activated and apoptosis induced by the death receptor pathway. The compound can inhibit the migration and invasion of tumor cells by down-regulating the expression of MMP-2 and MMP-9 proteins, has obvious effect and achieves the effect of resisting lung cancer. |
| priorityDate | 2018-10-23-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 93.