http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-109369779-B
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/Y02P20-55 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K5-0821 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K5-097 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K1-06 |
| filingDate | 2018-12-21-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2021-12-10-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2021-12-10-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-109369779-B |
| titleOfInvention | Synthetic method of taltirelin |
| abstract | The invention relates to a method for synthesizing taltirelin, which comprises the steps of condensing 2-cyano pyrrolidine serving as a starting material with amino and histidine protected by a side chain to form an amido bond, condensing with 1-methyl-4, 5-dihydroorotic acid, and finally oxidizing and deprotecting to obtain the taltirelin. The method completely avoids the step of forming Diketopiperazine (DKP) by the conventional method, so that the product has less impurities, is easy to purify, has high yield and is easy to recycle the solution. The method also shortens the synthesis period, avoids harsh reaction conditions in the traditional method, and has the advantages of high yield, good product purity, easy purification, low cost, mild reaction conditions and suitability for industrial production. |
| priorityDate | 2018-12-21-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 46.