http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-109369681-B
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D501-24 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D501-04 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D501-24 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D501-04 |
| filingDate | 2018-12-19-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2020-04-28-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2020-04-28-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-109369681-B |
| titleOfInvention | Preparation method of cefditoren pivoxil |
| abstract | The invention relates to the technical field of antibiotic preparation, and particularly discloses a preparation method of cefditoren pivoxil, which comprises the steps of taking 7-amino-3-chloromethyl-3-cephem-4-carboxylic acid as an initial raw material, carrying out an aldehyde reaction of iodomethyl pivalate and carboxyl in a structure, carrying out a chloromethyl aldehyde reaction, a Grignard reaction and dehydration to obtain 7-ATCA trimethyl acetoxyl methyl ester, and carrying out amidation on the 7-ATCA trimethyl acetoxyl methyl ester and 2-methoxyimino-2- (2-aminothiazole-4-yl) acetic acid to obtain cefditoren pivoxil. The method has the advantages of high yield, low cost, short time consumption and environmental protection. |
| priorityDate | 2018-12-19-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 60.