http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-109369631-B
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07B2200-07 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D405-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D409-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D409-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D417-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D333-20 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D333-24 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D333-22 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D405-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D409-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D409-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D417-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D333-24 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D333-22 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D333-20 |
| filingDate | 2018-12-11-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2020-06-30-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2020-06-30-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-109369631-B |
| titleOfInvention | Synthesis method of key intermediate for synthesizing lactate dehydrogenase A inhibitor |
| abstract | The invention relates to a synthesis method of a key intermediate 6, 6-aromatic ring substituted-2, 4-piperidedione (compound X) for synthesizing a lactate dehydrogenase A (LDHA) inhibitor, which takes a compound I as a raw material and prepares a compound IX through steps of addition, oxidation, substitution, acidolysis and the like, wherein the compound IX is prepared into the compound X through enzyme ring closure, and the compound X with a single configuration with an ee value higher than 99% can be prepared through the method; the reaction has the advantages of simple operation, simple and convenient post-treatment, high total yield, environmental protection and low cost, and is suitable for industrial production. |
| priorityDate | 2018-12-11-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 157.