http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-109369529-B
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P17-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P31-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D221-18 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D221-18 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P31-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P17-00 |
| filingDate | 2018-12-29-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2022-03-04-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2022-03-04-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-109369529-B |
| titleOfInvention | Method for preparing high-purity magnoflorine by taking coptis chinensis extraction mother liquor as raw material, high-purity magnoflorine prepared by method and application |
| abstract | The invention discloses a method for preparing high-purity magnoflorine by taking coptis chinensis extraction mother liquor as a raw material, high-purity magnoflorine prepared by the method and application of the high-purity magnoflorine, which comprise preparation, extraction and column chromatography of the mother liquor. Compared with the prior art, the method for preparing high-purity magnoflorine by taking the coptis chinensis extraction mother liquor as the raw material, the high-purity magnoflorine prepared by the method and the application have the advantages that the process flow is simple and easy to implement, the extraction efficiency is high, the mother liquor after the coptis chinensis total alkaloids are extracted is taken as the raw material, the waste is comprehensively utilized, the product cost is reduced, the separation efficiency of magnoflorine is greatly improved by adopting continuous twice silica gel column chromatographic purifications, the purity of the magnoflorine prepared can reach more than 90 percent, and the application prospect is wide; the inhibitory activity of magnoflorine on HaCaT apoptosis of human keratinocytes and tinea pedis pathogenic fungi is found, magnoflorine shows a trend of inhibiting HaCaT apoptosis at the concentration of more than 500ppm, MICs for inhibiting trichophyton rubrum and trichophyton mentagrophytes are both 62.5 mu g/mL, and the magnoflorine has an application prospect in treatment of eczema and beriberi. |
| priorityDate | 2018-12-29-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 79.