http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-109369519-B
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D211-90 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D213-85 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D213-85 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D211-90 |
| filingDate | 2018-10-23-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2021-05-04-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2021-05-04-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-109369519-B |
| titleOfInvention | Green preparation method of 2-chloro-3-cyanopyridine |
| abstract | The invention discloses a green preparation method of 2-chloro-3-cyanopyridine, which comprises the following steps: dissolving 3-cyanopyridine N-oxide serving as a raw material in a certain amount of organic solvent, adding an additive, organic base and a phase transfer catalyst to form a raw material system, controlling a proper temperature, dissolving bis (trichloromethyl) carbonate in a certain amount of organic solvent, slowly dropwise adding the solution into the raw material system for reaction, and obtaining the 2-chloro-3-cyanopyridine after the reaction is finished through simple treatment. The preparation method is simple, the reaction period is short, the green chlorination reagent is used for replacing the phosphorus-containing reagent, no heavy metal is involved, and compared with the prior art, the method has the advantages of small environmental pollution, safe operation and low cost, and is suitable for industrial production. The method is applied to green chlorination reaction of 3-cyanopyridine N-oxide, but is not limited to preparation of 2-chloro-3-cyanopyridine. |
| priorityDate | 2018-10-23-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 46.