http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-109369467-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_d281e953d189bcfe2507ba7faba72c25 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D233-48 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D231-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C277-08 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C279-22 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D295-215 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C279-22 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C277-08 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D295-215 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D231-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D233-48 |
| filingDate | 2018-11-21-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_8f76a3ddad50a36689e1c15211de86d0 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_60f7cc3674fcf638e295c7e5a88febd1 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_d404f389eacc6ff300b3452a0f02065d |
| publicationDate | 2019-02-22-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-109369467-A |
| titleOfInvention | A kind of N2Polyfluoroalkyl acyl group guanidine compound and preparation method thereof |
| abstract | The present invention relates to a kind of N 2 Polyfluoroalkyl acyl group guanidine compound and preparation method thereof.The N 2 Polyfluoroalkyl acyl group guanidine compound has the structure of general formula (I) or (II).The synthetic method of such compound is the following steps are included: guanidine compound or carbamide compounds or imidazolines are placed in a reaction flask, and addition organic solvent and Polyfluoroalkyl halogen stir 6-15 hours under room temperature and illumination, and TLC monitors reaction end；Products therefrom is poured into water, is extracted with dichloromethane, organic phase is collected, dry, vacuum distillation removes solvent；Gained crude product is isolated and purified to arrive N by the method for silica gel column chromatography 2 Polyfluoroalkyl acylguanidines product.Synthetic route of the present invention has the advantages that method is simple, at low cost, range is wide, mild condition, and reaction route is safe, easy to operate.Such compound can be used as potential histamine H 2 Receptor stimulating agent uses. Or |
| priorityDate | 2018-11-21-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
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