http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-109369425-B
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C51-09 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C51-43 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C51-42 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C51-47 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C213-10 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C51-47 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C59-90 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C215-40 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C213-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C51-09 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C51-43 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C51-42 |
| filingDate | 2018-11-05-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2022-01-04-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2022-01-04-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-109369425-B |
| titleOfInvention | Preparation method of fenofibric acid choline salt |
| abstract | The invention provides a preparation method of fenofibric acid choline salt, which comprises the following steps: (1) preparation of choline fenofibrate salt crude product: the fenofibrate and choline hydroxide are used as starting materials, and hydrolysis and salt forming reaction are carried out in a solvent A to obtain choline fenofibrate; wherein the solvent A is selected from one of methanol, ethanol, propanol, n-butanol, water, choline hydroxide aqueous solution and isopropanol; (2) refining fenofibric acid choline salt: dissolving the choline fenofibrate salt crude product prepared in the step (1) in a solvent B, decoloring by using activated carbon, cooling and crystallizing to obtain a choline fenofibrate salt refined product; wherein the solvent B is selected from one of ethanol, methanol, water and isopropanol. The preparation method of the fenofibric acid choline salt provided by the invention has the advantages of mild reaction conditions, simple preparation process, high reaction yield and product purity of more than 99.9%. |
| priorityDate | 2018-11-05-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 54.