http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-109364245-B
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K47-6949 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K49-22 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K47-34 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K41-0052 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K41-0071 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K49-22 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K47-34 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K47-69 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K41-00 |
| filingDate | 2018-09-04-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2021-06-25-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2021-06-25-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-109364245-B |
| titleOfInvention | Polydopamine nano diagnosis and treatment agent and preparation method thereof |
| abstract | The invention discloses a polydopamine nano diagnosis and treatment preparation and a preparation method thereof. The nano diagnosis and treatment agent takes mesoporous polydopamine as a carrier, rhodium nanoparticles are respectively loaded in holes and on the surface of the mesoporous polydopamine through a hydrothermal synthesis reaction, and then photosensitizer chlorin (Ce6) is adsorbed on the polydopamine and rhodium composite nanoparticles to obtain the polydopamine nano diagnosis and treatment agent with good dispersibility. The invention utilizes the photothermal effect of the carrier mesoporous polydopamine and rhodium nano particles to locally heat the tumor part. The catalytic property of the rhodium nanoparticles is combined, hydrogen peroxide in a tumor microenvironment is catalyzed to decompose to generate oxygen, and singlet oxygen is generated and cancer cells are effectively killed under the conditions of a photosensitizer Ce6 and additional laser. Meanwhile, by combining the photoacoustic imaging characteristic of polydopamine, the purpose of photoacoustic imaging-guided photothermal therapy and photodynamic cooperative therapy can be achieved, the tumor treatment effect is expected to be improved, the biocompatibility is good, and the poly dopamine-guided photothermal therapy has clinical application potential. |
| priorityDate | 2018-09-04-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 61.