http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-109355294-B
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2310-16 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N15-115 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N33-57484 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-711 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N33-68 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01N33-574 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01N33-68 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-115 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-711 |
| filingDate | 2018-11-16-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2022-06-28-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2022-06-28-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-109355294-B |
| titleOfInvention | Nucleic acid aptamer for specifically recognizing Vimentin and application thereof |
| abstract | The invention discloses a nucleic acid aptamer capable of identifying Vimentin and application thereof, wherein the sequence of the nucleic acid aptamer is shown as SEQ ID No. 1. The aptamer AptVim of the invention can specifically bind to Vimentin, and the Kd value is 70.9 +/-12.3 nM. After the AptVim terminal is connected with biotin or fluorescent molecules, the conventional Vimentin antibody can be replaced, the detection of Vimentin protein expressed by cells or tissues can be completed only by one step, and the method has the advantages of simpler required reaction conditions, higher stability and lower cost. In addition, the aptamer of the invention can induce tumor cells to undergo apoptosis after being introduced into the tumor cells by a proper transfection reagent. Not only can be used as an EMT diagnostic reagent for basic experiments and clinical cancers, but also can induce the apoptosis of tumor cells for tumor treatment. |
| priorityDate | 2018-11-16-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 79.