| abstract |
The invention discloses application of the spiral shell circle spore rhzomorph X in preparation treatment Flu-A drug.The influenza virus is influenza A virus, preferably H1N1, H3N2, H5N1 or H7N9.Mechanism of action in the full rhzomorph X anti-influenza A virus of spiral shell circle be by and the combination of PB2cap albumen inhibit ribonucleoprotein complexes vRNP activity, prepare the drug for preventing and treating influenza.Wherein, the arginine (Arg355) that the full rhzomorph X of spiral shell circle and the protein bound site influenza virus PB2cap are 355,429 asparagines (Asn429), 339 lysine (Lys339), 431 methionines (Met431), 325 phenylalanines (Phe325). |