http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-109336804-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_d40285e27f4ed83b8728b0d477404958 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D207-404 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D207-404 |
| filingDate | 2018-12-21-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_0b109026e7895181d90896c75f2f5aa4 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_2a9d77472d552655a7c8cd3c30ae57b3 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_50e0f236a8938d72e6df8e4d72e220f0 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_0e3df5e779dd5f2ba97455c8eb9197a5 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_c1c814e581002040cacb35381bceb0cc |
| publicationDate | 2019-02-15-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-109336804-A |
| titleOfInvention | A kind of method for synthesizing key intermediate of Sacubitril by pipeline chemical |
| abstract | The invention discloses a method for synthesizing a key intermediate of sacubitril by pipeline synthesis, comprising (S)-1-([1,1'-biphenyl]-4-yl)-3-chloropropane-2-alcohol , succinimide, triphenylphosphine, ethyl azodicarboxylate and organic solvent are mixed, the mixed liquid is continuously entered into the pipeline reactor for reaction, and the reacted feed liquid enters into the quenching liquid In the quenching kettle, the quenching reaction is carried out by the quenching liquid to prepare (R)-1-(1-([1,1'-biphenyl]-4-base)-3-chloropropane-2-base) Pyrrolidine-2,5-dione to obtain the key intermediate product of Sacubitril. Through the reaction process of the present invention, the reaction temperature, time, material ratio, etc. can be precisely controlled; the reactor has the advantages of large specific surface area, high mass transfer and heat transfer efficiency, the materials can be accurately proportioned instantly, and the heat transfer efficiency is high, ensuring that Safety of the production process. |
| isCitedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-113754565-B http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-113754565-A http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-113387841-A |
| priorityDate | 2018-12-21-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 40.