http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-109320466-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_e87252ee40e7f6061dcbe8608f8746c0 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D239-52 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D239-52 |
| filingDate | 2018-10-07-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2019-02-12-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-109320466-A |
| titleOfInvention | A kind of preparation method of small grain size Bosentan |
| abstract | The present invention relates to a kind of preparation methods of small grain size Bosentan, belong to bulk pharmaceutical chemicals preparation technical field.Bosentan crude product, is dissolved in methylene chloride by the purification process of small grain size Bosentan of the present invention first, filtering；Filtrate is cooled to 0 to 5 DEG C, and maintains, the 50-60% ethanol water of 1.8-3 times of stream plus first step solvent volume；Mixing speed is 220-250 revs/min, and the speed of stream plus ethanol water is 10-15ml/ points, after stream adds, continues stirring 4-5 hours；Filtering, washs filter cake with 50-60% ethanol water, dries.The present invention provides a kind of preparation method of small grain size Bosentan, prepared Bosentan D90 be can control at 16.89 microns to 32.56 microns, provide the bulk pharmaceutical chemicals that can directly use for Bosentan preparation. |
| priorityDate | 2018-10-07-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 21.