| abstract |
The invention discloses a fractional blade processing machine. The fractional lobe machine includes a barrel having a heating and cooling member having two parallel intersecting openings, the two openings having equal diameters, wherein the two openings are between The center-to-center distance is less than the diameter of the opening; the shaft is coupled with a plurality of helical elements to form a helix within each opening, wherein the helix is intermeshed, and wherein the helix forms at least three zones within the barrel, the zones comprising: an entry zone comprising at least one deep threaded shovel element on each of the intermeshing helices to receive a feed comprising active substance and/or excipient, a melting zone, consisting only of fractional lobe elements, with After melting the active substance and/or excipient to form a viscous slurry or melt, and a discharge zone, wherein the melt zone is located before the discharge zone and after the entry zone; and wherein the melt zone has a plurality of fractions on each axis leaf element. |