| abstract |
The present invention provides a method and apparatus for large-scale production of monodisperse microspheres and biodegradable polymer-based drug delivery systems, as well as a design optimization method for the apparatus. The method uses a plurality of microchips, each microchip having at least a first via, a second via, and an outlet, wherein the first via and the second via merge at an intersection that is one end of the outlet, and the method comprising preparing a polymer phase solution comprising a degradable polymer and an aqueous phase solution comprising a surfactant, wherein the polymer phase solution is passed through the first passage and the aqueous phase solution is passed through the first passage Two passages, collecting the mixed solution flowing out of the outlet, and collecting the microspheres by filtering out the aqueous phase solution. |