http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-109305986-B
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07F7-1892 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D307-93 |
| filingDate | 2018-11-13-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2021-02-19-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2021-02-19-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-109305986-B |
| titleOfInvention | Synthetic method of beraprost sodium intermediate |
| abstract | The invention relates to a synthesis method of a beraprost sodium intermediate I. The method specifically comprises the following steps: compound I b By reduction of the methyl ester to the corresponding alcohol compound I a (ii) a With compounds I a Mixing the raw materials with an organic solvent, alkali and a Wittig reagent, carrying out catalytic reaction by a catalyst PNN-Ru (II), and carrying out hydrogenation reduction to realize one-step olefin alkylation and debromination to prepare the I. The method has the advantages of short reaction route, high yield, safety and controllability, and capability of avoiding using dangerous reagents such as Grignard reagents and the like, and provides reference for amplification production. |
| priorityDate | 2018-11-13-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 42.