http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-109305941-B
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D233-38 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D403-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D401-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D401-14 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-506 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D401-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D401-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-454 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-4164 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-496 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D403-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D233-38 |
| filingDate | 2018-07-05-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2021-11-09-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2021-11-09-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-109305941-B |
| titleOfInvention | HDACs and MDM2 double-target-point inhibitor and preparation method and application thereof |
| abstract | The invention relates to a Histone Deacetylase (HDACs) and MDM2 dual-target inhibitor, and a preparation method and application thereof, wherein the compound is spliced by functional groups of an HDAC inhibitor (SAHA, CI-994) and an MDM2 inhibitor (Nutlin-3, RG 7112). Its advantages are: (1) the invention not only shows good HDACs and MDM2 enzyme inhibition activity, but also has a certain broad spectrum in vitro anti-tumor activity, can obviously delay tumor growth, and can be applied to the tumor diseases with pathological characteristics mediated by HDACs and MDM 2. (2) The compound is used as a double-target anti-tumor medicament based on HDACs and MDM2 for the first time, and has further development and research values. |
| priorityDate | 2018-07-05-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 146.