http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-109293765-B
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K49-225 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K14-765 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K41-0052 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K19-00 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K14-765 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K1-107 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K49-22 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K41-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P35-00 |
| filingDate | 2018-09-13-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2022-04-01-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2022-04-01-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-109293765-B |
| titleOfInvention | polyaniline-BSA with high pH response and preparation and application thereof |
| abstract | The invention relates to polyaniline-BSA with high pH response, and preparation and application thereof, wherein the polyaniline-BSA is mainly used for preparing tumor photo-thermal diagnosis and treatment agents and the like, and the preparation method comprises the steps of taking functional albumin (BSA) as a biological template and utilizing the sensitivity of the BSA to pH to form BSA-transition metal ion Fe 3+ The coordination compound is used for regulating and controlling the synthesis of coordination polymerization, and simultaneously, aniline monomer acidified by HCl, BSA-Fe are added 3+ And reacting for 6 hours in an ice bath environment at 4 ℃ by using a chemical oxidation method, standing for 12 hours in a refrigerator, and performing ultrafiltration and water washing for multiple times to obtain the polyaniline-BSA nano particles with high pH response. Compared with the prior art, the invention has sensitive triggering property, good biocompatibility and the combination of polyaniline and BSA, can be doped in a relatively high pH environment, and improves the condition that the prior polyaniline needs to be doped at a pH value<3, the condition that the intrinsic state is changed into the doped state ensures that the polyaniline can be well applied to the diagnosis and treatment integration of tumors, and the application range of the polyaniline is expanded. |
| priorityDate | 2018-09-13-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 36.