http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-109289046-B
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K2039-55516 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N15-70 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K14-195 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K39-39 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K39-114 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P31-04 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-31 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K39-114 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-70 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K39-39 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P31-04 |
| filingDate | 2018-11-15-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2021-10-12-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2021-10-12-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-109289046-B |
| titleOfInvention | Fusobacterium nucleatum FomA protein vaccine and preparation method and application thereof |
| abstract | The disclosure relates to a fusobacterium nucleatum FomA protein vaccine and a preparation method and application thereof. Firstly, connecting the FomA gene which is removed with a signal peptide sequence and is connected with the MBP label to an expression vector, then transforming escherichia coli, after induced expression, carrying out affinity purification on the FomA recombinant protein by using an aminose Resin High Flow, and finally carrying out enzyme digestion on the MBP label by using tev enzyme to remove the FomA protein vaccine of the fusobacterium nucleatum; the vaccine has good stability, can effectively improve the immunity of organisms to fusobacterium nucleatum, improve the survival rate and delay the occurrence and development of colon tumors; in an APCMin/+ mouse model, the FomA protein vaccine has a remarkable protective effect on a mouse, can be used as a new colon tumor vaccine candidate, and has a great application prospect. |
| priorityDate | 2018-11-15-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 328.