http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-109283263-B
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N30-02 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01N30-02 |
| filingDate | 2017-07-21-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2019-06-25-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2019-06-25-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-109283263-B |
| titleOfInvention | Detection and analysis method for synthetic quality control of raltitrexed |
| abstract | The invention discloses a detection and analysis method for synthetic quality control of raltitrexed, which comprises starting material 6-bromomethyl-3,4-dihydro-2-methyl-quinazoline-4-one Purity testing, purity testing of starting material 5-nitro-2-thiophenecarboxylic acid, content determination of raltitrexed, 6-bromomethyl-3,4-dihydro-2-methyl-quinoline in raltitrexed oxazoline-4-ketone, 6-hydroxymethyl-3,4-dihydro-2-methyl-quinazoline-4-one and 5-nitro-2-thiophenecarboxylic acid content detection and raltitrexed Enantiomer detection. The method of the invention has the characteristics of high sensitivity and strong specificity, and can quickly and accurately control the quality of the raltitrexed synthesis process, thereby ensuring the quality of the raltitrexed raw material medicine. |
| priorityDate | 2017-07-21-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 65.