http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-109280055-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_1e74277852f1aae0a3ff13f59a65456d |
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07B2200-07 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/Y02P20-55 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07B53-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D457-02 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D457-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07B53-00 |
| filingDate | 2017-07-20-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_cb64c74aa80df29ab41d449819122866 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_a2a2fa5b31b658474b62cfa7be294dcb |
| publicationDate | 2019-01-29-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-109280055-A |
| titleOfInvention | The method of asymmetric synthesis of ergot alkaloid |
| abstract | The invention discloses a kind of method of asymmetric synthesis of ergot alkaloid, belong to chemosynthesis technical field.After the present invention passes through alkylation using compound 1 and 3 cheap and easy to get, restore cyano, then and after the condensation of the tertiary fourth sulfenamide of R configuration, restore nitro, amino is protected using acetyl group, Larock cyclization precursor compound is obtained using the chirality of tertiary fourth sulfenamide control zincon addition, being made again with the Larock cyclization of palladium chtalyst has 3, the midbody compound of 4- bridged ring indole structure, it is set out again with midbody compound and converts to obtain chiral natural products Festuclavine by several steps, Pyroclavine, Costaclavine, epi-Costaclavine, Pibocin A, 9-Deacetoxyfumigaclavine C, Fumigacl AvineG and Dihydrosetoclavine.The present invention uses completely new synthetic strategy, reacts repeatability height, operability is good, can satisfy the needs of large-scale industrial production. |
| isCitedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-110330495-A http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-114031582-A |
| priorityDate | 2017-07-20-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 179.