http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-109276573-B
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07J63-008 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-56 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-00 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07J63-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-56 |
| filingDate | 2018-12-04-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2021-06-11-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2021-06-11-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-109276573-B |
| titleOfInvention | Application of sea-derived sesterterpene compounds as drugs for treating cervical cancer |
| abstract | An application of a sea-derived sesterterpene compound as a medicine for treating cervical cancer relates to a sesterterpene compound. The marine sesterterpene compound 12-deacetyl-12-epi-scalamdial can be applied to preparation of a target medicine for resisting cervical cancer. The sea-derived sesterterpene compound 12-deacetyl-12-epi-scalamdial is obtained from sea-derived sponge by various separation and purification means, can target a nuclear receptor Nur77 and inhibit the proliferation of a cervical cancer cell HeLa, has an obvious effect of inducing PARP cleavage and is time-concentration dependent; moreover, caspase 3 and caspase 8 can be activated, and the apoptosis of HeLa cells is induced by an exogenous way. Therefore, the compound can be applied as a target drug for treating cervical cancer. Provides a new way for treating cervical cancer. |
| priorityDate | 2018-12-04-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 70.