http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-109270179-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_c6ed83b9d5c28c6c356d1d08d58501e7 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N30-08 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N30-02 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01N30-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01N30-08 |
| filingDate | 2018-10-22-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_5f6cb04355eafc0355f1f8501f1bd449 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_e8386e8fe796110db3946f8f01263165 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_cedb60ee7339cb2f3659bab53c0af566 |
| publicationDate | 2019-01-25-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-109270179-A |
| titleOfInvention | A method for screening iNOS inhibitors in Ophiopogon japonicus and screening for iNOS inhibitors |
| abstract | The invention discloses a method for screening iNOS inhibitors in Ophiopogon japonicus and screening for iNOS inhibitors. First, through molecular docking and chemically pure iNOS inhibition experiments, the screening method disclosed in the present invention can effectively and reliably screen compounds having iNOS inhibitory activity in Ophiopogon japonicus, including: Pennogenin‐3‐O‐α‐L‐rhamnopyranosyl ‐(1→2)‐β‐D‐xylopyranosyl‐(1→4)‐β‐D-glucopyranoside, Ophiocohol ketone A, Methyl sterol flavanone A, Methyl dextran B, Aspartame D and dextran D'; secondly, from another perspective, the method disclosed in the present invention can be used to target the above-mentioned iNOS inhibitor in Ophiopogon japonicus; again, the above chemical composition in Ophiopogon japonicus is the first time It has been found to have iNOS inhibitory activity, and thus can be prepared as an iNOS inhibitor for the treatment of diseases caused by excessive NO such as hypertension, neurodegeneration, rheumatoid arthritis, colitis, cancer, and the like. |
| isCitedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-113181192-A |
| priorityDate | 2018-10-22-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 63.