http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-109265507-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_da488acbf12d11e33fe3429bf853bf9f |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07J5-0061 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07J5-00 |
| filingDate | 2018-11-13-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_5aa56c41e3d84d5ced1dd221054bd060 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_abef5856fdb4e6d38d8838ce3318dc3b http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_8bca7e2cf28107a06f457a3915a1d537 |
| publicationDate | 2019-01-25-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-109265507-A |
| titleOfInvention | Method for preparing 16a-hydroxyprednisolone |
| abstract | The invention provides a method for preparing 16a-hydroxyprednisolone, which comprises using 17a-dehydroxyprednisolone as a raw material, firstly starting the raw material 17a-dehydroxyprednisolone in the first organic solvent, The organic peroxyacid is epoxidized at the 16th and 17th positions to obtain an epoxy; the epoxy is reacted in a second organic solvent with glacial acetic acid under the catalysis of an acid catalyst to form a 16a. , 21-diacetoxyprednisolone; then, 16a, 21-diacetoxyprednisolone is dissolved in a third organic solvent, under the catalysis of a solid phase base catalyst, at two positions The acetate is hydrolyzed to prepare 16a-hydroxyprednisolone. The solid phase base catalyst is a catalyst which adsorbs sodium carbonate or sodium hydroxide on a carrier by using alumina, silica gel or calcium carbonate as a carrier. The invention prepares 16α-hydroxyprednisolone in an efficient, environmentally friendly and cost-effective manner. |
| priorityDate | 2018-11-13-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 98.