http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-109265377-B
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C303-40 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C311-21 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C303-40 |
| filingDate | 2018-10-25-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2021-01-22-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2021-01-22-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-109265377-B |
| titleOfInvention | Green synthesis method of belinostat |
| abstract | The invention belongs to the technical field of pharmaceutical chemicals, and particularly relates to a green synthesis method of belinostat. Reacting hydroxylamine salt with an alkaline compound by using water as a solvent to obtain a free hydroxylamine solution; and adding the compound I into a free hydroxylamine solution for reaction, adding acid to adjust the pH value to 2-9 after the reaction is finished, separating out a solid, filtering, and washing with water to obtain the belinostat. The synthesis method avoids the use of a large amount of organic solvents, is simple and convenient to operate, has a short reaction route and low cost, is green and pollution-free by taking water as the solvent, is environment-friendly, improves the reaction yield and the purity of a target product, and is more suitable for the requirement of industrial amplification production. |
| priorityDate | 2018-10-25-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 63.