| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_d6a6f422b091ba12ea61d4adbf1b0e8e
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_74aa06ec79aa5d9eccca46e6e3ce0bf9 |
| classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C2601-02 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D213-64
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C255-37
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C205-36
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C43-225 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C41-16
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C253-30
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D213-64
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C255-37
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C43-225
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C201-12
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C205-36 |
| filingDate |
2018-10-31-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_9f4d268d673022e3a91ad69aa7d65049
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_d800f4bd1caaae4a9af1bc5ba9a13706
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_7cdca50d80033e836619e797bb359009
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_b467a1391d5ee48f4d380545f84a70a8 |
| publicationDate |
2019-01-25-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
CN-109265352-A |
| titleOfInvention |
Method for preparing arylcyclopropyl ether and derivatives thereof |
| abstract |
The invention discloses a preparation method of an arylcyclopropyl ether and a derivative thereof: under the protection of an inert gas, a fluoroaromatic compound and a cyclopropanol are dissolved in an aprotic dipolar solvent, and then a base is added. The aromatic nucleophilic substitution reaction is carried out at 0 to 75 ° C for 2 to 6 hours under stirring; after the reaction time is reached, the obtained reaction solution is quenched with water, and the quenched reaction solution is extracted, washed, dried and filtered. The filtrate is subjected to rotary evaporation to remove the extractant to obtain a crude product of the product as an arylcyclopropyl ether or a derivative thereof. The invention solves the defects that the prior art has low product yield and the stable existence of the cyclopropoxide salt, provides a suitable base and a matching solvent, and uses a one-pot method to make the fluoroaromatic compound and the ring The propanol is capable of directly undergoing an aromatic nucleophilic substitution reaction to form an arylcyclopropyl ether and a derivative thereof. |
| priorityDate |
2018-10-31-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |