http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-109260463-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_24ae3ff27b64d8d6516ec5127c1ac829 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K38-4886 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K9-5036 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P9-10 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P9-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K9-50 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K38-48 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K47-36 |
| filingDate | 2018-10-25-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_5d3a290d5ae35218dc3b0a970441b27d http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_fbaf3172319c62ca93ba1c624b207bd3 |
| publicationDate | 2019-01-25-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-109260463-A |
| titleOfInvention | Medicine composition for treating and/or preventing myocardial ischemia reperfusion injury and preparation method thereof |
| abstract | The invention belongs to the field of biomedicine, and particularly relates to a pharmaceutical composition for treating and/or preventing myocardial ischemia-reperfusion injury and a preparation method thereof. The pharmaceutical composition is a chitosan nanoparticle entrapped with a recombinant APN protein. The pharmaceutical composition of the invention is a nanoparticle prepared by recombinant APN protein and chitosan, and the encapsulation efficiency thereof is up to 81.9%; the nanoparticle morphology is a spheroid, the particle size is less than 700 nm, and the concentration is between 100 and 500 nm. The pharmaceutical composition of the present invention can improve left ventricular systolic and diastolic function in rats with myocardial ischemia-reperfusion injury and inhibit myocardial mitochondrial autophagy. |
| priorityDate | 2018-10-25-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 601.